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Befetupitant

Catalog No. T14524 CAS 290296-68-3

Synonyms: Ro67-5930

Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.

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Befetupitant, CAS 290296-68-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 490.00
5 mg	In stock	$ 1,070.00
10 mg	In stock	$ 1,300.00
25 mg	In stock	$ 1,715.00
50 mg	In stock	$ 2,180.00
100 mg	In stock	$ 2,800.00

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Purity: 98.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.

In vivo

In the alkali burn model, Befetupitant, a highly selective NK1R antagonist, was tested. Hemangiogenesis and lymphangiogenesis were effectively reduced (P<0.05) after topical application of Befetupitant for 4 days at both concentrations (0.4 and 1.6 mg/mL). However, both Befetupitant and its vehicle DMSO induced corneal opacity even in healthy controls, as observed during slit-lamp examination. Furthermore, fluorescein and hematoxylin-eosin staining confirmed DMSO toxicity by revealing epithelial damage and inflammatory cellular infiltration in the stroma. Despite Befetupitant's effectiveness in reducing corneal neovascularization (CNV) in the alkali burn model, its toxicity due to the DMSO vehicle led to the decision not to test it in the suture model[1].

Synonyms	Ro67-5930
Molecular Weight	565.55
Formula	C29H29F6N3O2
CAS No.	290296-68-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bignami F, et al. NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6783-94.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library

Related Products

Related compounds with same targets

Aprepitant Neurokinin A (R)-CJ 11974 Substance P (7-11) Fosaprepitant dimeglumine Fezolinetant Physalaemin Hemokinin 1 (human) acetate(491851-53-7 free base)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Befetupitant 290296-68-3 Neuroscience GPCR/G Protein Neurokinin receptor Ro67-5930 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.