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Bax inhibitor peptide V5 acetate

Catalog No. T10463L CAS T10463L

Synonyms: Bax inhibitor peptide V5 acetate（579492-81-2 free base)

Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate（579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

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Bax inhibitor peptide V5 acetate Chemical Structure

Bax inhibitor peptide V5 acetate, CAS T10463L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 61.00
5 mg	In stock	$ 90.00
10 mg	In stock	$ 132.00
25 mg	In stock	$ 290.00
50 mg	In stock	$ 478.00
100 mg	In stock	$ 619.00
200 mg	In stock	$ 809.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 99.2%

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Description	Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate（579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
In vitro	Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) decreases cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells.[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].
In vivo	Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].

Synonyms	Bax inhibitor peptide V5 acetate（579492-81-2 free base)
Molecular Weight	646.85
Formula	C29H54N6O8S
CAS No.	T10463L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (170.42 mM), Sonification is recommended.

DMSO: 100 mg/mL (170.42 mM)

References and Literature

1. Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65. 2. Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Peptide Compound Library Apoptosis Compound Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bax inhibitor peptide V5 acetate T10463L Apoptosis 579492-81-2 free base Bax inhibitor peptide V5 Acetate Bax inhibitor peptide V5 acetate（579492-81-2 free base) Bax inhibitor peptide V-5 acetate 579492-81-2 inhibitor inhibit

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