keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS.
Description | Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS. |
In vitro | The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3 integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca2+·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited [1]. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (Kd: 27.5 μM) and locates at the survivin C-terminus [4]. |
In vivo | Administering Arg-Gly-Asp-Ser at doses of 2.5 or 5 mg/kg, one hour before lipopolysaccharide (LPS), significantly inhibits LPS-induced matrix metallopeptidase-9 (MMP-9) activity in bronchoalveolar lavage (BAL) fluid four hours after LPS exposure. Similarly, Arg-Gly-Asp-Ser given intraperitoneally (i.p.) at doses of 1, 2.5, or 5 mg/kg, one hour before LPS, effectively suppressed the LPS-induced increases in tumor necrosis factor-alpha (TNF-α) and macrophage inflammatory protein (MIP)-2 levels in BAL fluid at the four-hour mark post-LPS [2]. Furthermore, the Arg-Gly-Asp-Ser peptide significantly lowers TNF-α and MIP-2 production and reduces myeloperoxidase (MPO) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity [3]. |
Synonyms | Fibronectin tetrapeptide, RGDS peptide |
Molecular Weight | 433.42 |
Formula | C15H27N7O8 |
CAS No. | 91037-65-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (126.90 mM)
H2O: 25 mg/mL (57.68 mM)
You can also refer to dose conversion for different animals. More
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Arg-Gly-Asp-Ser 91037-65-9 Others ArgGlyAspSer Fibronectin tetrapeptide RGDS peptide Arg Gly Asp Ser inhibitor inhibit