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Arctiin

Catalog No. T2766 CAS 20362-31-6

Synonyms: Arctigenin-4-glucoside, NSC 315527, Arctii

Arctiin acts on an agonists of the Adiponectin receptor 1 with anti-cancer effects.

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Arctiin, CAS 20362-31-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
In vitro	Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].
In vivo	Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].
Cell Research	HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)

Synonyms	Arctigenin-4-glucoside, NSC 315527, Arctii
Molecular Weight	534.55
Formula	C27H34O11
CAS No.	20362-31-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 37 mg/mL (69.2 mM)

Ethanol: 93 mg/mL (174 mM)

DMSO: 93 mg/mL (174 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Matsuzaki Y, et al. Oncol Rep. 2008, 19(3):721-7. 2. Hayashi K, et al. Biol Pharm Bull. 2010, 33(7):1199-205. 3. Sun Y, et al. PLoS One. 2013, 8(5):e63354.

Citations

1. Liu Y, Hou M, Pan Z, et al. Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression. Journal of Nanobiotechnology. 2022, 20(1): 1-20

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Arctiin 20362-31-6 GPCR/G Protein Adiponectin receptor Inhibitor NSC315527 NSC-315527 inhibit Arctigenin-4-glucoside NSC 315527 Arctii inhibitor

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