Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Arctiin acts on an agonists of the Adiponectin receptor 1 with anti-cancer effects.
Description | Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects. |
In vitro | Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1]. |
In vivo | Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3]. |
Cell Research | HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference) |
Synonyms | Arctigenin-4-glucoside, NSC 315527, Arctii |
Molecular Weight | 534.55 |
Formula | C27H34O11 |
CAS No. | 20362-31-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 37 mg/mL (69.2 mM)
Ethanol: 93 mg/mL (174 mM)
DMSO: 93 mg/mL (174 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Arctiin 20362-31-6 GPCR/G Protein Adiponectin receptor Inhibitor NSC315527 NSC-315527 inhibit Arctigenin-4-glucoside NSC 315527 Arctii inhibitor