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Catalog No. T2766   CAS 20362-31-6
Synonyms: Arctigenin-4-glucoside, Arctii, NSC 315527

Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.

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Arctiin Chemical Structure
Arctiin, CAS 20362-31-6
Pack Size Availability Price/USD Quantity
25 mg In stock $ 34.00
50 mg In stock $ 48.00
100 mg In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 53.00
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Purity: 99.81%
Purity: 99.81%
Purity: 98.22%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
In vitro Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].
In vivo Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].
Cell Research HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)
Synonyms Arctigenin-4-glucoside, Arctii, NSC 315527
Molecular Weight 534.55
Formula C27H34O11
CAS No. 20362-31-6


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 37 mg/mL (69.2 mM)

Ethanol: 93 mg/mL (174 mM)

DMSO: 50 mg/mL (93.54 mM)

TargetMolReferences and Literature

1. Matsuzaki Y, et al. Oncol Rep. 2008, 19(3):721-7. 2. Hayashi K, et al. Biol Pharm Bull. 2010, 33(7):1199-205. 3. Sun Y, et al. PLoS One. 2013, 8(5):e63354.


1. Liu Y, Hou M, Pan Z, et al. Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression. Journal of Nanobiotechnology. 2022, 20(1): 1-20

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Natural Product Library for HTS GPCR Compound Library Natural Product Library Traditional Chinese Medicine Monomer Library Anti-Metabolism Disease Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Toxic Compound Library Bioactive Compounds Library Max

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Arctiin 20362-31-6 GPCR/G Protein Adiponectin receptor Inhibitor NSC315527 Arctigenin-4-glucoside NSC-315527 Arctii inhibit NSC 315527 inhibitor