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Acebilustat

Catalog No. T3715 CAS 943764-99-6

Synonyms: CTX-4430

Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Acebilustat, CAS 943764-99-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 585.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.59%

Purity: 99.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
In vitro	Acebilustat, a potent leukotriene A4 hydrolase (LTA4H) inhibitor, demonstrated safety and tolerability in a phase 1 trial[1]. Currently under development as an anti-inflammatory medication, it targets CF among other diseases by inhibiting LTA4H, the crucial enzyme in leukotriene B4 (LTB4) production. LTB4 acts as a powerful chemoattractant and activator for inflammatory immune cells, such as neutrophils[2], thus Acebilustat's mechanism holds promise for mitigating inflammatory responses.
Kinase Assay	Rolapitant is made at a stock concentration of 1 mM in 100% DMSO. For most receptor binding studies, the stock solution is diluted with the final concentrations ranged from 0.1 to 3 μM. Radioligand concentrations for competition binding studies ranged from 0.5 to 1 nM. For species comparison studies, 150 pM [125I]-BHSP is incubated with varying concentrations of protein (10-50 μg) prepared from gerbil, rabbit and monkey striata, and from cells expressing cloned rat, mouse and guinea pig NK receptors[1].

Synonyms	CTX-4430
Molecular Weight	481.54
Formula	C29H27N3O4
CAS No.	943764-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

Methanol: 32 mg/mL

References and Literature

1. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2. 2. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library NO PAINS Compound Library Metabolism Compound Library Orally Active Compound Library Clinical Compound Library Nonsteroidal Anti-Inflammatory Compound Library Immunology/Inflammation Compound Library ReFRAME Related Library Coagulation and Anticoagulation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acebilustat 943764-99-6 Immunology/Inflammation Metabolism Aminopeptidase LTR CTX 4430 Inhibitor inhibit CTX4430 CTX-4430 inhibitor

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