Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
Description | AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1). |
Targets&IC50 | HSET/KIFC1:300 nM, HSET/KIFC1:43 nM (ki) |
In vitro | AZ82 specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome numbers, such as HeLa [1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes for mant-ATP binding/releasing (IC50: 0.90 μM/1.26 μM) [2]. |
Molecular Weight | 560.63 |
Formula | C28H31F3N4O3S |
CAS No. | 1449578-65-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (222.96 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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AZ82 1449578-65-7 Cytoskeletal Signaling Microtubule Associated AZ 82 AZ-82 inhibitor inhibit