Shopping Cart

Your shopping cart is currently empty

AZ13705339

Name: AZ13705339
Brand: TargetMol
SKU: T26704
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T26704Cas No. 2016806-57-6

Alias AZ-13705339, AZ 13705339

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

AZ13705339

Copy Product Info

🥰Excellent

Purity: 99.77%

Catalog No. T26704Alias AZ-13705339, AZ 13705339Cas No. 2016806-57-6

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$355	In Stock	In Stock
100 mg	$572	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.
Targets&IC50	PAK1:0.33 nM, PAK2:0.32 nM (Kd), PAK1:0.28 nM (Kd), pPAK1:59 nM
In vitro	AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death[2]. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion[3].
In vivo	In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM[1].
Synonyms	AZ-13705339, AZ 13705339

Chemical Properties

Molecular Weight	629.75
Formula	C₃₃H₃₆FN₇O₃S
Cas No.	2016806-57-6
Smiles	CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (357.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5879 mL	7.9397 mL	15.8793 mL	79.3966 mL
5 mM	0.3176 mL	1.5879 mL	3.1759 mL	15.8793 mL
10 mM	0.1588 mL	0.7940 mL	1.5879 mL	7.9397 mL
20 mM	0.0794 mL	0.3970 mL	0.7940 mL	3.9698 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5879 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7940 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc