Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 218.00 | |
10 mg | In stock | $ 319.00 | |
25 mg | In stock | $ 459.00 | |
50 mg | In stock | $ 689.00 | |
100 mg | In stock | $ 1,028.00 | |
500 mg | In stock | $ 2,508.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 258.00 |
Description | Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively. |
Targets&IC50 | AT1:>10 μM(ki), AT2:0.4 nM(ki) |
In vivo | Buloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rats. Which induces the outgrowth of neurite cells, stimulates p42/p44mapk, and enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats. And it lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats.[1] |
Synonyms | AT2 receptor agonist C21 |
Molecular Weight | 475.62 |
Formula | C23H29N3O4S2 |
CAS No. | 477775-14-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (47.31 mM)
You can also refer to dose conversion for different animals. More
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Buloxibutid 477775-14-7 Endocrinology/Hormones RAAS AT2 receptor agonist C21 inhibitor inhibit