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ACP-105

Catalog No. T14116 CAS 899821-23-9

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

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ACP-105, CAS 899821-23-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 278.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 572.00
500 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
Targets&IC50	AR (T877A):9.3 (pEC50), AR (WT):9.0 (pEC50)
In vitro	ACP-105 is an orally administered, selective, and potent androgen receptor modulator (SARM), demonstrating high affinity with pEC50 values of 9.0 and 9.3 for the AR wild type and T877A mutant, respectively. In human hepatocytes, the half-life of ACP-105 (compound 1) is determined to be 5.0 hours[1].
In vivo	Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance[2].

Molecular Weight	290.79
Formula	C16H19ClN2O
CAS No.	899821-23-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (206.33 mM)

Ethanol: 60 mg/mL(206.33 mM)

References and Literature

1. Schlienger N, et al. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. J Med Chem. 2009 Nov 26;52(22):7186-91. 2. Dayger C, et al. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011 Mar 24;1381:134-40.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Nuclear Receptor Compound Library Orally Active Compound Library Transcription Factor-Targeted Compound Library Endocrinology-Hormone Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ACP-105 899821-23-9 Endocrinology/Hormones Androgen Receptor ACP 105 inhibit ACP105 Inhibitor inhibitor

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