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6-Benzoylheteratisine

Catalog No. TN6713 CAS 99759-48-5

Synonyms: Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth

6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes

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6-Benzoylheteratisine Chemical Structure

6-Benzoylheteratisine, CAS 99759-48-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 285.00
5 mg	In stock	$ 687.00
10 mg	In stock	$ 998.00
25 mg	In stock	$ 1,480.00
50 mg	In stock	$ 1,990.00
1 mL * 10 mM (in DMSO)	In stock	$ 855.00

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Purity: 99.87%

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Storage & Solubility Information

Description

6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes

In vitro

A concentration-dependent inhibitory effect of 6-benzoylheteratisine on aconitine-induced increases in [Na+]i, [Ca2+]i and the release of glutamate.?The IC50 values were 4.1 microM (Na+), 4.8 microM (Ca2+) and 4.8 microM (glutamate release).?Application of 100 microM 6-benzoylheteratisine after stimulation with 5 microM veratridine also reduced the induced [Na+]i and [Ca2+]i with half-lives of 72.1 and 44.7 s, respectively.?Furthermore, 100 microM 6-benzoylheteratisine reduced the ouabain-induced Na+ influx to the same extent as the Na+ channel inhibitor tetrodotoxin, which points to an inhibition of non-activated Na+ channels by 6-benzoylheteratisine.?Additionally, 100 microM 6-benzoylheteratisine failed to affect the release of glutamate and the increase in [Ca2+]i induced by 30 mM KCl, indicating that voltage-gated Ca2+ channels were not affected by 6-benzoylheteratisine.?The data suggest an inhibitory effect of 6-benzoylheteratisine on voltage-gated Na+ channels as the only target, whereas mechanisms of Na+ and Ca2+ homoeostasis and pathways of glutamate release seem not to be affected by the drug[1].

Synonyms	Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth
Molecular Weight	495.61
Formula	C29H37NO6
CAS No.	99759-48-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (50.44 mM)

References and Literature

2. Gutser U T , Gleitz J . The alkaloid 6-benzoylheteratisine inhibits voltage-gated Na+ channels in rat brain synaptosomes.[J]. Neuropharmacology, 1998, 37(9):1139-1146.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS Selected Plant-Sourced Compound Library Natural Product Library Sodium Channel Blocker Library RO5 Drug-like Natural Product Library Anti-Cancer Compound Library NO PAINS Compound Library

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Related compounds with same targets

µ-Conotoxin BuIIIC Clopamide Bupivacaine hydrochloride DSP-2230 Phlotoxin-1 R 56865 µ-Conotoxin-CnIIIC Ropivacaine

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Keywords

6-Benzoylheteratisine 99759-48-5 Membrane transporter/Ion channel Sodium Channel Inhibitor 6Benzoylheteratisine inhibit Na+ channels Na channels 6 Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth inhibitor

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