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2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid)

Catalog No. T14014 CAS 2086689-02-1

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].

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2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid), CAS 2086689-02-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	461.53
Formula	C19H31N3O8S
CAS No.	2086689-02-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) 2086689-02-1 Others 2-(Biotin-amido)-1,3-bis-(C-1-PEG1-acid) 2 (Biotin amido) 1,3 bis (C1 PEG1 acid) 2(Biotinamido)1,3bis(C1PEG1acid) inhibitor inhibit

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