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1,2-Bis(2-iodoethoxy)ethane

Catalog No. T17319 CAS 36839-55-1

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

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1,2-Bis(2-iodoethoxy)ethane Chemical Structure

1,2-Bis(2-iodoethoxy)ethane, CAS 36839-55-1

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Description	1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
In vitro	1,2-Bis(2-iodoethoxy)ethane serves as a PROTAC linker, specifically belonging to the polyethylene glycol (PEG) class. This compound plays a crucial role in synthesizing various PROTACs, including MT802 and SJF620. Notably, PROTAC MT802 incorporates a ligand targeting BTK and another ligand targeting the E3 ligase cereblon (CRBN), both bridged by the PEG linker 1,2-Bis(2-iodoethoxy)ethane[1].

Molecular Weight	369.97
Formula	C6H12I2O2
CAS No.	36839-55-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

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Keywords

1,2-Bis(2-iodoethoxy)ethane 36839-55-1 Others PROTAC PROTAC Linker inhibit Inhibitor PROTAC Linkers 1,2 Bis(2 iodoethoxy)ethane 1,2Bis(2iodoethoxy)ethane inhibitor

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