Vasopressin acetate, a cyclic nonapeptide, is synthesized centrally in the hypothalamus. Vasopressin acetate acts as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.

Vasopressin acetate participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin acetate (0.01 nM-1 μM) induces Ca2+ increase in Chinese hamster ovary cells expressing rat or human V1b receptors[1].

Vasopressin acetate (0.03-0.3 μg/kg; i.p.) increases corticotropin secretion subsequent to body water loss and potentiated corticotropin release provoked by exogenous corticoliberin[1]. Vasopressin acetate (0.001-0.1 mg/kg; i.p.) was increased when lying