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t-Boc-Aminooxy-PEG7-amine

Catalog No. T18743 CAS 2226611-29-4

t-Boc-Aminooxy-PEG7-amine is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker for synthesizing PROTACs[1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

t-Boc-Aminooxy-PEG7-amine, CAS 2226611-29-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	t-Boc-Aminooxy-PEG7-amine is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker for synthesizing PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	484.58
Formula	C21H44N2O10
CAS No.	2226611-29-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

t-Boc-Aminooxy-PEG7-amine 2226611-29-4 Others tBocAminooxyPEG7amine t-Boc-Aminooxy-PEG-7-amine t Boc Aminooxy PEG7 amine inhibitor inhibit

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