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PDE9-IN-(S)-C33

Name: PDE9-IN-(S)-C33
Brand: TargetMol
SKU: T28352
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28352Cas No. 2066488-39-7

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

PDE9-IN-(S)-C33

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Purity: 98.75%

Catalog No. T28352Cas No. 2066488-39-7

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$95	In Stock	In Stock
25 mg	$155	In Stock	In Stock
50 mg	$230	In Stock	In Stock
100 mg	$343	In Stock	In Stock
200 mg	$489	-	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.75%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PDE9-IN-(S)-C33 AI Summary

PDE9-IN-(S)-C33 demonstrates an inhibitory activity on the PDE9A enzyme with an IC50 value of 11.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.
Targets&IC50	PDE10A1:2.3 ± 0.3 μM, PDE4D2:1.3 ± 0.1 μM, PDE1B:554 ± 64 nM, PDE5A1:366 ± 38 nM, PDE9A:11 ± 4 nM, PDE2A:2.4 ± 0.5 μM

Chemical Properties

Molecular Weight	357.84
Formula	C₁₈H₂₀ClN₅O
Cas No.	2066488-39-7
Smiles	O=C1C2=C(N(N=C2)C3CCCC3)NC(N[C@@H](C)C4=CC=C(Cl)C=C4)=N1
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (265.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7945 mL	13.9727 mL	27.9455 mL	139.7273 mL
5 mM	0.5589 mL	2.7945 mL	5.5891 mL	27.9455 mL
10 mM	0.2795 mL	1.3973 mL	2.7945 mL	13.9727 mL
20 mM	0.1397 mL	0.6986 mL	1.3973 mL	6.9864 mL
50 mM	0.0559 mL	0.2795 mL	0.5589 mL	2.7945 mL
100 mM	0.0279 mL	0.1397 mL	0.2795 mL	1.3973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc