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ZM241385

Catalog No. T7021 CAS 139180-30-6

ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.

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ZM241385, CAS 139180-30-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 135.00
50 mg	In stock	$ 245.00
100 mg	In stock	$ 455.00
200 mg	In stock	$ 687.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.69%

Purity: 99.06%

Purity: 95.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
Targets&IC50	A2AR:1.4 nM (Ki)
In vitro	ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7?min) OGD period, and protect CA1 neuron and astrocyte from injury[4].
In vivo	ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1].
Cell Research	Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference)

Molecular Weight	337.34
Formula	C16H15N7O2
CAS No.	139180-30-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1.7 mg/mL (5 mM)

DMSO: 33.7 mg/mL (100 mM)

References and Literature

1. Lasley RD, et al. Am J Physiol Heart Circ Physiol. 2007, 292(1):H426-31. 2. Wang Z, et al. PLoS One. 2010, 5(11):e13883. 3. S. M. Poucher, et al. Br J Pharmacol. 1995 Jul; 115(6): 1096–1102. 4. Pedata F, et al. Mediators Inflamm. 2014: 805198.

Citations

1. Luo Y, Xue Y, Lin Q, et al. CD39 pathway inhibits Th1 cell function in tuberculosis. Immunology. 2022

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Immuno-Oncology Compound Library Neuronal Signaling Compound Library Anti-Alzheimer's Disease Compound Library Preclinical Compound Library

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Keywords

ZM241385 139180-30-6 GPCR/G Protein Neuroscience Adenosine Receptor P1 receptor Inhibitor inhibit ZM 241385 ZM-241385 inhibitor

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