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YTX-465

Catalog No. T9722 CAS 2225824-53-1

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).

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YTX-465, CAS 2225824-53-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 622.00
10 mg	In stock	$ 983.00
25 mg	In stock	$ 1,460.00
50 mg	In stock	$ 1,970.00
100 mg	In stock	$ 2,650.00
1 mL * 10 mM (in DMSO)	In stock	$ 713.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
Targets&IC50	SCD:30.4 μM, Ole1:39 nM
In vitro	YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1].

Molecular Weight	458.51
Formula	C25H26N6O3
CAS No.	2225824-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (109.05 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Metabolism Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Inhibitor Library

Related Products

Related compounds with same targets

CVT-12012 MF-438 PluriSIn 1 CAY10566 XEN723 GSK1940029 SCD1 inhibitor-4 A939572

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YTX-465 2225824-53-1 Metabolism Stearoyl-CoA Desaturase (SCD) α-synuclein YTX465 fatty desaturation Inhibitor YTX 465 Parkinson’s disease inhibit synucleinopathies inhibitor

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