Powder: -20°C for 3 years | In solvent: -80°C for 2 years
YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 622.00 | |
10 mg | In stock | $ 983.00 | |
25 mg | In stock | $ 1,460.00 | |
50 mg | In stock | $ 1,970.00 | |
100 mg | In stock | $ 2,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 713.00 |
Description | YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM). |
Targets&IC50 | SCD:30.4 μM, Ole1:39 nM |
In vitro | YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1]. |
Molecular Weight | 458.51 |
Formula | C25H26N6O3 |
CAS No. | 2225824-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 50 mg/mL (109.05 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
YTX-465 2225824-53-1 Metabolism Stearoyl-CoA Desaturase (SCD) α-synuclein YTX465 fatty desaturation Inhibitor YTX 465 Parkinson’s disease inhibit synucleinopathies inhibitor