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YTX-465

Catalog No. T9722 CAS 2225824-53-1

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).

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YTX-465, CAS 2225824-53-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
Targets&IC50	SCD:30.4 μM, Ole1:39 nM
In vitro	YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1].

Molecular Weight	458.522
Formula	C25H26N6O3
CAS No.	2225824-53-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.

Related Products

Related compounds with same targets

YTX-465 CVT-12012 GSK1940029 A939572 Elemicin MK-8245 PluriSIn 1 MF-438

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YTX-465 2225824-53-1 代谢 Stearoyl-CoA Desaturase (SCD) α-synuclein YTX465 fatty desaturation Inhibitor YTX 465 Parkinson’s disease inhibit synucleinopathies inhibitor

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