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Tranylcypromine hemisulfate

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Purity:98%

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COA HNMR

Tranylcypromine hemisulfate

Catalog No. T7942Cas No. 13492-01-8

Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.

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Pack Size	Price	Availability	Quantity
100 mg	$48	In Stock

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Product Introduction

Bioactivity

Description	Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
In vivo	Tranylcypromine-induced transcriptional and epigenetic regulation modulated RGC survival via the promotion of p38 MAPKγ activity. Therefore, pharmacologic treatments that suppress LSD1 activity may be a novel therapeutic strategy that can be used to treat neurodegenerative diseases[1].
Animal Research	The authors evaluated whether tranylcypromine contributes to neuronal survival following stress-induced damage using primary cultured rat RGCs and in vivo N-methyl-D-aspartate (NMDA)-induced excitotoxicity.?Additionally, the molecules associated with tranylcypromine treatment were assessed by microarray and immunoblot analysis[1].
Alias	Tranylcypromine Sulfate, Tranylcypromine (hemisulfate)

Chemical Properties

Molecular Weight	182.23
Formula	C9H11N 1/2H2SO4
Cas No.	13492-01-8

Storage & Solubility Information

Storage

store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (54.8 mM), Sonication is recommended.

DMSO: 3.33 mg/mL (18 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4876 mL	27.4379 mL	54.8757 mL	274.3785 mL
5 mM	1.0975 mL	5.4876 mL	10.9751 mL	54.8757 mL
10 mM	0.5488 mL	2.7438 mL	5.4876 mL	27.4379 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.2744 mL	1.3719 mL	2.7438 mL	13.7189 mL
50 mM	0.1098 mL	0.5488 mL	1.0975 mL	5.4876 mL
100 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7438 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc