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Tranylcypromine hemisulfate

Catalog No. T7942 CAS 13492-01-8

Synonyms: Tranylcypromine (hemisulfate), Tranylcypromine Sulfate, 反苯环丙胺半硫酸盐

Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.

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Tranylcypromine hemisulfate, CAS 13492-01-8

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Purity: 98%

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Description	Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
In vivo	Tranylcypromine-induced transcriptional and epigenetic regulation modulated RGC survival via the promotion of p38 MAPKγ activity. Therefore, pharmacologic treatments that suppress LSD1 activity may be a novel therapeutic strategy that can be used to treat neurodegenerative diseases[1].
Animal Research	The authors evaluated whether tranylcypromine contributes to neuronal survival following stress-induced damage using primary cultured rat RGCs and in vivo N-methyl-D-aspartate (NMDA)-induced excitotoxicity.?Additionally, the molecules associated with tranylcypromine treatment were assessed by microarray and immunoblot analysis[1].

Synonyms	Tranylcypromine (hemisulfate), Tranylcypromine Sulfate, 反苯环丙胺半硫酸盐
Molecular Weight	364.46
Formula	C18H24N2O4S
CAS No.	13492-01-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mg/mL (27.44 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Takayuki T , Keiichiro I , Hideki H , et al. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity[J]. Investigative Opthalmology & Visual Science, 2016, 57(14):6461-. 2. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1–42)-induced toxicity[J]. European Journal of Pharmacology, 2015, 764:256-263.

Related compound libraries

This product is contained In the following compound libraries：

Histone Modification Compound Library Chromatin Modification Compound Library Epigenetics Compound Library CNS-Penetrant Compound Library

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Keywords

Tranylcypromine hemisulfate 13492-01-8 表观遗传代谢神经科学 Histone Demethylase MAO Monoamine Oxidase Tranylcypromine Sulfate dl-Tranylcypromine hemisulfate Tranylcypromine (hemisulfate) inhibit Inhibitor inhibitor

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