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Tranylcypromine hemisulfate

Catalog No. T7942   CAS 13492-01-8
Synonyms: Tranylcypromine Sulfate, Tranylcypromine (hemisulfate)

Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.

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Tranylcypromine hemisulfate Chemical Structure
Tranylcypromine hemisulfate, CAS 13492-01-8
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100 mg In stock $ 48.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
In vivo Tranylcypromine-induced transcriptional and epigenetic regulation modulated RGC survival via the promotion of p38 MAPKγ activity. Therefore, pharmacologic treatments that suppress LSD1 activity may be a novel therapeutic strategy that can be used to treat neurodegenerative diseases[1].
Animal Research The authors evaluated whether tranylcypromine contributes to neuronal survival following stress-induced damage using primary cultured rat RGCs and in vivo N-methyl-D-aspartate (NMDA)-induced excitotoxicity.?Additionally, the molecules associated with tranylcypromine treatment were assessed by microarray and immunoblot analysis[1].
Synonyms Tranylcypromine Sulfate, Tranylcypromine (hemisulfate)
Molecular Weight 182.23
Formula C9H11N 1/2H2SO4
CAS No. 13492-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (54.8 mM), Sonification is recommended

DMSO: 3.33 mg/mL (18 mM), Sonification is recommended

TargetMolReferences and Literature

1. Takayuki T , Keiichiro I , Hideki H , et al. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity[J]. Investigative Opthalmology & Visual Science, 2016, 57(14):6461-. 2. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1–42)-induced toxicity[J]. European Journal of Pharmacology, 2015, 764:256-263.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Histone Modification Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Methylation Compound Library Bioactive Compounds Library Max Bioactive Compound Library Chromatin Modification Compound Library Antidepressant Compound Library Epigenetics Compound Library

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Keywords

Tranylcypromine hemisulfate 13492-01-8 Chromatin/Epigenetic Metabolism Neuroscience MAO Histone Demethylase Monoamine Oxidase dl-Tranylcypromine hemisulfate Tranylcypromine Tranylcypromine Hemisulfate inhibit Tranylcypromine Sulfate Inhibitor Tranylcypromine (hemisulfate) inhibitor

 

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