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Tranylcypromine hemisulfate

Tranylcypromine hemisulfate
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Purity:98%
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Tranylcypromine hemisulfate

Catalog No. T7942Cas No. 13492-01-8
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
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Pack SizePrice/USDAvailabilityQuantity
100 mg$48In Stock
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Related Compound Libraries of "Tranylcypromine hemisulfate"

Product Introduction

Bioactivity
Description
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
In vivo
Tranylcypromine-induced transcriptional and epigenetic regulation modulated RGC survival via the promotion of p38 MAPKγ activity. Therefore, pharmacologic treatments that suppress LSD1 activity may be a novel therapeutic strategy that can be used to treat neurodegenerative diseases[1].
Animal Research
The authors evaluated whether tranylcypromine contributes to neuronal survival following stress-induced damage using primary cultured rat RGCs and in vivo N-methyl-D-aspartate (NMDA)-induced excitotoxicity.?Additionally, the molecules associated with tranylcypromine treatment were assessed by microarray and immunoblot analysis[1].
AliasTranylcypromine Sulfate, Tranylcypromine (hemisulfate)
Chemical Properties
Molecular Weight182.23
FormulaC9H11N 1/2H2SO4
Cas No.13492-01-8
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 10 mg/mL (54.8 mM)
DMSO: 3.33 mg/mL (18 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.4876 mL27.4379 mL54.8757 mL274.3785 mL
5 mM1.0975 mL5.4876 mL10.9751 mL54.8757 mL
10 mM0.5488 mL2.7438 mL5.4876 mL27.4379 mL
H2O
1mg5mg10mg50mg
20 mM0.2744 mL1.3719 mL2.7438 mL13.7189 mL
50 mM0.1098 mL0.5488 mL1.0975 mL5.4876 mL
100 mM0.0549 mL0.2744 mL0.5488 mL2.7438 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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