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Taiwanin C

Catalog No. TN6284 CAS 14944-34-4

Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.

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Taiwanin C, CAS 14944-34-4

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5 mg	Inquiry	$ 1,850.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 2,200.00

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Biological Description

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Description	Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.
Targets&IC50	COX-2:9.31 μM, COX-1:9.31 μM
In vitro	Taiwanin C (1-60μM,24h) demonstrated a dose-dependent inhibition of cell viability specifically in T28 cells, while it had no impact on the normal N28 cells. Treatment with Taiwanin C dose-dependently suppressed the migration ability of T28 cells, as assessed by wound healing and migration assays. Additionally, Taiwanin C decreased the levels of β-catenin, as well as its downstream metastatic proteins Tbx3 and cMyc. Furthermore, Taiwanin C hindered the nuclear accumulation of β-catenin and facilitated its degradation through a pathway involving proteasomes. Moreover, Taiwanin C enhanced the activity of GSK-3β and reduced the levels of phosphorylated (p-ser9) GSK-3β, thereby inactivating the Wnt signaling pathway. In summary, Taiwanin C impeded the cell migration effects of T28 cells by activating GSK-3β, which led to enhanced protein degradation and reduced nuclear accumulation of β-catenin.[1]
In vivo	Taiwanin C (20 mg/kg/d, 30 mg/kg/d, 15d; injected) showed effective anti_x0002_tumor activity in nude mice models.[1]

Molecular Weight	348.31
Formula	C20H12O6
CAS No.	14944-34-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hsieh CH, et al. Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation. Mol Carcinog. 2017;56(3):1055-1067. 2. Ban HS, et al. Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action. Biochem Pharmacol. 2002;64(9):1345-1354.

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Keywords

Taiwanin C 14944-34-4 Immunology/Inflammation oxidation-reduction Antioxidant Immunology/Inflammation related inhibitor inhibit

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