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Sparfloxacin

Catalog No. T1095 CAS 110871-86-8

Synonyms: AT-4140, PD 131501, Zagam, CI-978

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.

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Sparfloxacin, CAS 110871-86-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 42.00
100 mg	In stock	$ 57.00
200 mg	In stock	$ 77.00
500 mg	In stock	$ 119.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.95%

Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
In vitro	Orally administered Sparfloxacin produces favorable therapeutic outcomes in mice with systemic infections caused by Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
In vivo	Sparfloxacin targets DNA gyrase, inhibiting DNA synthesis. It exhibits potent, broad-spectrum antimicrobial activity, effective against Gram-positive bacteria such as Staphylococcus, Streptococcus, and Enterococcus species (MIC=0.1 to 0.78μg/ml), Gram-negative bacteria including Enterobacteriaceae and Pseudomonas species (MIC=0.0125 to 1.56μg/ml), glucose non-fermenters (MIC=0.025 to 0.78μg/ml), Legionella (MIC=0.0125 to 0.05μg/ml), and anaerobes (MIC=0.2 to 0.78μg/ml).

Synonyms	AT-4140, PD 131501, Zagam, CI-978
Molecular Weight	392.4
Formula	C19H22F2N4O3
CAS No.	110871-86-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (22.93 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Nakamura S, et al. Antimicrob Agents Chemother, 1989, 33(8), 1167-1173. 2. Pan XS, et al. Antimicrob Agents Chemother, 1997, 41(2), 471-474.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Cardiotoxicity Compound Library ReFRAME Related Library Approved Drug Library FDA-Approved Drug Library Bioactive Compounds Library Max Anti-Infection Compound Library FDA-Approved & Pharmacopeia Drug Library DNA Damage & Repair Compound Library

Related Products

Related compounds with same targets

Tryptanthrin BRD7116 Novobiocin Sodium Ciprofloxacin monohydrochloride Zoliflodacin Novobiocin Alalevonadifloxacin Levofloxacin hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sparfloxacin 110871-86-8 DNA Damage/DNA Repair Microbiology/Virology Antibacterial Topoisomerase DNA gyrase Antibiotic CI978 AT 4140 AT-4140 AT4140 Inhibitor inhibit PD 131501 Zagam PD131501 Bacterial PD-131501 CI 978 CI-978 inhibitor

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