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Sparfloxacin
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Catalog No. T1095Cas No. 110871-86-8
Alias Zagam, PD 131501, CI-978, AT-4140
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thus preventing DNA replication and transcription.
Sparfloxacin
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Purity: 99.99%
Catalog No. T1095Alias Zagam, PD 131501, CI-978, AT-4140Cas No. 110871-86-8
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thus preventing DNA replication and transcription.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $38 | In Stock | In Stock | |
| 1 g | $48 | In Stock | In Stock | |
| 5 g | $112 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.99%
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thus preventing DNA replication and transcription. |
| In vitro | Orally administered Sparfloxacin produces favorable therapeutic outcomes in mice with systemic infections caused by Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. |
| In vivo | Sparfloxacin targets DNA gyrase, inhibiting DNA synthesis. It exhibits potent, broad-spectrum antimicrobial activity, effective against Gram-positive bacteria such as Staphylococcus, Streptococcus, and Enterococcus species (MIC=0.1 to 0.78μg/ml), Gram-negative bacteria including Enterobacteriaceae and Pseudomonas species (MIC=0.0125 to 1.56μg/ml), glucose non-fermenters (MIC=0.025 to 0.78μg/ml), Legionella (MIC=0.0125 to 0.05μg/ml), and anaerobes (MIC=0.2 to 0.78μg/ml). |
| Synonyms | Zagam, PD 131501, CI-978, AT-4140 |
| Molecular Weight | 392.40 |
| Formula | C19H22F2N4O3 |
| Cas No. | 110871-86-8 |
| Smiles | FC1=C2C(C(=O)C(C(O)=O)=CN2C3CC3)=C(N)C(F)=C1N4C[C@H](C)N[C@H](C)C4 |
| Relative Density. | 1.436g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1.45 mg/mL (3.7 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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