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STING agonist-4

Catalog No. T13015 CAS 2138300-40-8

STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).

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STING agonist-4, CAS 2138300-40-8

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Purity: 98%

Biological Description

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Description	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
Targets&IC50	STING agonist-4:20 nM
In vitro	STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.

Molecular Weight	678.74
Formula	C34H38N12O4
CAS No.	2138300-40-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL (14.73 mM), Need ultrasonic

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443.

Related Products

Related compounds with same targets

STING activator Compound 53 SN-008 SN-011 STING-IN-3 STING-IN-2 MSA-2 STING agonist-1 C-178

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Keywords

STING agonist-4 2138300-40-8 免疫与炎症 STING TMEM173 MPYS Inhibitor STING agonist 4 Stimulator of Interferon Genes inhibit ERIS STING agonist4 MITA inhibitor

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