Powder: -20°C for 3 years
In solvent: -80°C for 2 years
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
Description | STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM). |
Targets&IC50 | STING agonist-4:20 nM |
In vitro | STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1. |
Molecular Weight | 678.74 |
Formula | C34H38N12O4 |
CAS No. | 2138300-40-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mg/mL (14.73 mM), Need ultrasonic
H2O: < 0.1 mg/mL (insoluble)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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STING agonist-4 2138300-40-8 免疫与炎症 STING TMEM173 MPYS Inhibitor STING agonist 4 Stimulator of Interferon Genes inhibit ERIS STING agonist4 MITA inhibitor