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STING agonist-4
😃Good
Catalog No. T13015Cas No. 2138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
STING agonist-4
😃Good
Catalog No. T13015Cas No. 2138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 50 mg | Preferential | Backorder |
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Purity:≥98%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM). |
| Targets&IC50 | STING agonist-4:20 nM |
| In vitro | STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1. |
| Molecular Weight | 678.74 |
| Formula | C34H38N12O4 |
| Cas No. | 2138300-40-8 |
| Smiles | CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (14.73 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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