Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
Description | SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades. |
In vitro | Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy[2]. |
Molecular Weight | 400.486 |
Formula | C23H24N6O |
CAS No. | 1392816-46-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 65 mg/mL (162.31 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SI-113 1392816-46-4 代谢 SGK SI113 SI 113 Inhibitor inhibitor inhibit