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SI-113

Catalog No. T9589 CAS 1392816-46-4

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

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SI-113, CAS 1392816-46-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

In vitro

Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy[2].

Molecular Weight	400.486
Formula	C23H24N6O
CAS No.	1392816-46-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 65 mg/mL (162.31 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Matteoni S, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. 2. Talarico C, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016 Mar 29;7(13):15868-84.

Related Products

Related compounds with same targets

SGK1-IN-4 SI-113 EMD638683 URMC-099 GSK 650394 AT13148 Ro-3306 CKI-7

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Keywords

SI-113 1392816-46-4 代谢 SGK SI113 SI 113 Inhibitor inhibitor inhibit

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