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Roxithromycin

Catalog No. T1151   CAS 80214-83-1
Synonyms: Roxl-150, RU-28965

Roxithromycin (RU-28965) is a semi-synthetic derivative of the macrolide antibiotic erythromycin with antibacterial and anti-malarial activities.

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Roxithromycin Chemical Structure
Roxithromycin, CAS 80214-83-1
Pack Size Availability Price/USD Quantity
1 g In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.29%
Purity: 99.17%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Roxithromycin (RU-28965) is a semi-synthetic derivative of the macrolide antibiotic erythromycin with antibacterial and anti-malarial activities.
Kinase Assay The half-maximal inhibitory concentrations (IC50s) of Fenofibrate, statins (atorvastatin, lovastatin, pravastatin, simvastatin and simvastatin acid, the active form of simvastatin) and glipizide for recombinant human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 are determined using fluorometric CYP450 inhibition assays. Briefly, the drugs are dissolved in methanol or acetonitrile. In 96 well assay plates, the drugs are diluted to a series of concentrations in a solution containing cofactors including NADP+ (final concentration 1.3 mM), MgCl2 (final concentration 3.3 m M), glucose-6-phosphate (G6P, final concentration 3.3 mM) and glucose 6-phosphate dehydrogenase (final concentration 0.4 U/mL). The mixture is pre-incubated at 37°C for 10 min. The enzymes and fluorogenic substrates are diluted to desired concentrations in sodium phosphate reaction buffer (pH 7.4, final concentration 200 mM) and mixed. Reactions are initiated with addition of the enzyme and substrate mixture to the cofactor and drug mixture. The final reaction volume of all assays is 200 μL. After incubating at 37°C for a pre-specified period of time (15 to 45 min), the reactions are stopped with addition of 75 μL quenching solution (0.5 M Tris base or 2N NaOH). Fluorescence is determined using a BioTek Synergy 2 fluorescence reader. Each of the drugs is tested at eight concentrations in duplicate. To estimate IC50s, percent of inhibition is calculated using net fluorescence that is corrected for the background. The values of percent of inhibition are then fitted to a three or four parameter log-logistic model[1].
Synonyms Roxl-150, RU-28965
Molecular Weight 837.05
Formula C41H76N2O15
CAS No. 80214-83-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 154 mg/mL (184 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 154 mg/mL (184 mM)

TargetMolReferences and Literature

1. Bertho G, et al. Bioorg Med Chem. 1998 Feb;6(2):209-21.

TargetMolCitations

1. Li H, Li J, Li J, et al.Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.Acta Pharmaceutica Sinica B.2024

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Antiparasitic Natural Product Library Clinical Compound Library Approved Drug Library Anti-Infection Compound Library Anti-Bacterial Compound Library Natural Product Library for HTS Drug Repurposing Compound Library Target-Focused Phenotypic Screening Library Anti-Parasitic Compound Library

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Related compounds with same targets
Sulfacetamide sodium monohydrate Metamizole magnesium Tetramisole hydrochloride Tazobactam Streptozocin 2-Phenylethanol Doxycycline Sulfadimethoxine

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Roxithromycin 80214-83-1 Microbiology/Virology Antibiotic Antibacterial ribosome Roxl-150 RU 28965 Inhibitor RU-28965 Bacterial inhibit RU28965 inhibitor

 

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