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Ronacaleret HCl

Catalog No. T34385 CAS 702686-96-2

Synonyms: SB 751689, SB 751689A, SB-751689A, SB-751689, SB751689A, SB751689

Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ronacaleret HCl, CAS 702686-96-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 290.00
5 mg	In stock	$ 713.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,480.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,730.00

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Purity: 99.58%

ee: 100%

Biological Description

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Description

Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.

In vivo

For 569 postmenopausal women with low BMD offered open-label 20 μg teriparatide sc once daily or were randomized to 100, 200, 300, or 400 mg oral Ronacaleret HCl once daily, 70 mg alendronate once weekly, or placebo and were followed for up to 12 months.Results: With Ronacaleret HCl, the increases in lumbar spine BMD at 12 months (0.3-1.6%) were significantly lower than those attained with teriparatide (9.1%) or alendronate (4.5%). There were small decreases in total hip, femoral neck, and trochanter BMD at month 12 with Ronacaleret HCl compared with increases in the teriparatide and alendronate arms. Bone turnover markers increased in the Ronacaleret HCland teriparatide arms and decreased in the alendronate arm. PTH elevations with Ronacaleret HCl were prolonged relative to those previously reported with teriparatide. Conclusion: The densitometric findings in the context of prolonged PTH elevation and increased bone turnover suggest Ronacaleret HClinduces mild hyperparathyroidism. Ronacaleret HCl only modestly increased lumbar spine BMD and decreased BMD at hip sites.[1]

Synonyms	SB 751689, SB 751689A, SB-751689A, SB-751689, SB751689A, SB751689
Molecular Weight	483.98
Formula	C25H32ClF2NO4
CAS No.	702686-96-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fitzpatrick LA, et al. The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density. J Clin Endocrinol Metab. 2011;96(8):2441-2449. 2. Vogt FG, et al. Solid-state NMR analysis of a complex crystalline phase of ronacaleret hydrochloride. J Phys Chem B. 2014 Aug 28;118(34):10266-84. 3. Fitzpatrick LA, et al. Bone mineral density changes following discontinuation of ronacaleret treatment: off-treatment extension of a randomized, dose-finding phase II trial. Bone. 2014 Oct;67:104-8. 4. Fitzpatrick LA, et al. Ronacaleret, a calcium-sensing receptor antagonist, increases trabecular but not cortical bone in postmenopausal women. J Bone Miner Res. 2012;27(2):255-262.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

NPS-2143 hydrochloride SB-423562 AC265347 Etelcalcetide hydrochloride NPS-2143 Tecalcet Hydrochloride Strontium ranelate Ligustroflavone

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Keywords

Ronacaleret HCl 702686-96-2 GPCR/G Protein CaSR SB 751689 SB 751689A SB-751689A SB-751689 SB751689A SB751689 inhibitor inhibit

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