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Radioprotectin-1

Catalog No. T12684 CAS 1622006-09-0

Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.

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Radioprotectin-1, CAS 1622006-09-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 199.00
2 mg	In stock	$ 299.00
5 mg	In stock	$ 399.00
10 mg	In stock	$ 677.00
25 mg	In stock	$ 1,177.00
1 mL * 10 mM (in DMSO)	In stock	$ 451.00

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Purity: 99.43%

Purity: 98.75%

Biological Description

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Description	Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
Targets&IC50	murine LPA2 subtype:（EC50）25 nM
In vitro	In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin[1].
In vivo	In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome[1].

Molecular Weight	486.93
Formula	C23H19ClN2O6S
CAS No.	1622006-09-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (205.4 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kuo B, et al. The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids. Cell Signal. 2018 Nov;51:23-33.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

TAK-615 Tetradecyl Phosphonate ONO-7300243 Ki16198 Ki16425 H2L5186303 GRI977143 DBIBB

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Keywords

Radioprotectin-1 1622006-09-0 GPCR/G Protein LPA Receptor Inhibitor inhibitor inhibit

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