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Radioprotectin-1

Catalog No. T12684   CAS 1622006-09-0
Synonyms: 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid

Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.

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Radioprotectin-1 Chemical Structure
Radioprotectin-1, CAS 1622006-09-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 123.00
5 mg In stock $ 297.00
10 mg In stock $ 455.00
25 mg In stock $ 747.00
50 mg In stock $ 987.00
100 mg In stock $ 1,360.00
1 mL * 10 mM (in DMSO) In stock $ 327.00
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Purity: 99.43%
Purity: 98.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
Targets&IC50 LPA2 subtype (murine):(EC50)25 nM
In vitro In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin[1].
In vivo In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome[1].
Synonyms 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid
Molecular Weight 486.92
Formula C23H19ClN2O6S
CAS No. 1622006-09-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (205.4 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Kuo B, et al. The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids. Cell Signal. 2018 Nov;51:23-33.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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BMS-986278 GRI977143 1-Oleoyl lysophosphatidic acid sodium TAK-615 ONO-7300243 Ki16425 Edg-2 receptor inhibitor 1 TC LPA5 4

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Keywords

Radioprotectin-1 1622006-09-0 GPCR/G Protein LPA Receptor 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid inhibitor inhibit

 

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