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RG7834

Catalog No. T12719   CAS 2072057-17-9
Synonyms: RO 7020322

RG7834 (RO 7020322) is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).

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RG7834 Chemical Structure
RG7834, CAS 2072057-17-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
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1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.89%
Purity: 98.00%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RG7834 (RO 7020322) is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).
Targets&IC50 HBeAg:2.6 nM , HBsAg:2.8 nM , HBV DNA:3.2 nM
In vitro RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable inhibitor of HBV, RG7834 ((S)-(+)-64) potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells. RG7834 has no activity against CYP3A4, CYP2D6, CYP2C9 (IC50s >50 μM) or hERG channel.
In vivo In HBV-infected human liver chimeric uPA-SCID mice,RG7834 shows anti-HBV efficacy. RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, and with a half-life of 4.9 h in mice.
Synonyms RO 7020322
Molecular Weight 401.45
Formula C22H27NO6
CAS No. 2072057-17-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (311.37 mM), sonification is recommended.

TargetMolReferences and Literature

1. Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Clinical Compound Library Inhibitor Library Anti-Viral Compound Library Bioactive Compound Library Bioactive Compounds Library Max ReFRAME Related Library

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Keywords

RG7834 2072057-17-9 Microbiology/Virology HBV Hepatitis B virus RO7020322 RG 7834 inhibit Inhibitor RO 7020322 RG-7834 RO-7020322 inhibitor

 

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