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Propargyl-PEG14-acid

Catalog No. T18572 CAS T18572

Propargyl-PEG14-acid is a PEG-based PROTAC Linker that can be used in the synthesis of PROTACs[1].

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Propargyl-PEG14-acid, CAS T18572

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Propargyl-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	700.81
Formula	C32H60O16
CAS No.	T18572

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Propargyl-PEG14-acid T18572 Others Propargyl-PEG-14-acid PropargylPEG14acid Propargyl PEG14 acid inhibitor inhibit

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