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Plantamajoside

Catalog No. T3409 CAS 104777-68-6

Synonyms: Y0160, C10485

Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.

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Plantamajoside, CAS 104777-68-6

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 100.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.82%

Purity: 99.72%

Purity: 98%

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Description	Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.
Kinase Assay	Ca2+ Fluorescence Assay: SH-EP1 human epithelial cells expressing a variant of theα7 nAChR (α7) are grown in minimal essential medium (MEM) containing nonessential amino acids supplemented with 10% fetal bovine serum, L-glutamine, 100 U/ml penicillin/streptomycin, 250 ng/mL fungizone, 400 μg/mL hygromycin B, and 800 μg/mL geneticin. α7 is a variant of the human α7 nAChR, with two point mutations in the first transmembrane domain (T230P and C241S) that allow for high functional expression in SH-EP1 cells [Groppi VE, Wolfe ML, Berkenpas MB (2003) U.S. Patent 6,693,172 B1]. Cells are grown in a 37 °C incubator with 6% CO2. Cells are trypsinized and plated in 96-well plates with dark side walls and clear bottoms at a density of 2 × 104 cells/well 2 days before analysis. Cells are loaded with a mixture of Calcium reen-1AM in anhydrous dimethylsulfoxide and 20% pluronic F-127. This reagent is added directly to the growth medium of each well to achieve a final concentration of 2 μM Calcium Green-1 AM. Cells are then incubated in the dye for 1 hour at 37 °C and then washed four times with Mark's modified Earle's balanced salt solution (MMEBSS) composed of the following (inmM): 4 CaCl2, 0.8 MgSO4, 20 NaCl, 5.3 KCl, 5.6 D-glucose, 20 Tris-HEPES, and 120 N-methyl-D-glucamine, pH 7.4. After the fourth cycle, the cells are allowed to incubate at 37 °C for at least 10 minutes. The final volume of MMEBSS in each well is 100 μL and atropine is added to all wells for a final concentration of 1 μM. A fluorometric imaging plate reader (FLIPR; Molecular Devices, Union City, CA) is set up to excite Calcium Green at 488 nm using 500 mW of power and reading fluorescence emission of >525 nm. A 0.5 seconds exposure is used to illuminate each well. Fluorescence is detected using an F-stop set of either 2.0 or 1.2. After 30 seconds of baseline recording, test compounds are added to each well of a 96-well plate in 50 μL of a 3 × stock.In each experiment, four wells are used as vehicle (0.2% DMSO) controls.
Source	Natural Products > Plantaginaceae > Plantago

Synonyms	Y0160, C10485
Molecular Weight	640.59
Formula	C29H36O16
CAS No.	104777-68-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(142.1 mM)

Pyridine, Methanol, Ethanol, etc.: Soluble

References and Literature

1. Sun Q, et al. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2095-8. 2. Jung HY, et al. Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36. 3. Koo YC, et al. Phytother Res. 2009 Oct;23(10):1479-81.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Natural Product Library Bioactive Compounds Library Max Anti-Aging Compound Library Chinese Pharmacopoeia Natural Product Library The Yao nationality medicine Library Covalent Inhibitor Library Anti-Fibrosis Compound Library Tibetan medicine Compound Library Human Metabolite Library

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Keywords

Plantamajoside 104777-68-6 Others lung injury ALI inhibit Y0160 Inhibitor glycoside Y 0160 pulmonary acute C10485 C-10485 C 10485 Y-0160 phenylpropanoid inflammation inhibitor

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