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Perfluorooctanoic acid

Name: Perfluorooctanoic acid
Brand: TargetMol
SKU: T9333
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9333Cas No. 335-67-1

Alias PFOA

Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.

Perfluorooctanoic acid

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Purity: 99.70%

Catalog No. T9333Alias PFOACas No. 335-67-1

Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$75	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$192	In Stock	In Stock
100 mg	$287	In Stock	In Stock
200 mg	$431	In Stock	In Stock
500 mg	$713	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.70%

Appearance:Solid

Color:White

Resource Download

COA FNMR LCMS

Product Introduction

Bioactivity

Description	Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.
Targets&IC50	3β-HSD:53.2μM, 17β-HSD3: 17.7μM
In vitro	Perfluorooctanoic acid exposure impaired the tight junction of corneal cells and caused inflammatory reactions in the retina. Exposure of the cornea to perfluorooctanoic acid contained in particulate matter might induce oxidative stress and inflammation in the retina and represent a risk factor for age-related macular degeneration[1]. PFOA had toxic effects on SMMC-7721 cells, such as inhibiting cell proliferation and inducing apoptosis[2].
Synonyms	PFOA

Chemical Properties

Molecular Weight	414.07
Formula	C₈HF₁₅O₂
Cas No.	335-67-1
Smiles	C(C(C(C(C(O)=O)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
Relative Density.	1.7

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (579.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4151 mL	12.0753 mL	24.1505 mL	120.7525 mL
5 mM	0.4830 mL	2.4151 mL	4.8301 mL	24.1505 mL
10 mM	0.2415 mL	1.2075 mL	2.4151 mL	12.0753 mL
20 mM	0.1208 mL	0.6038 mL	1.2075 mL	6.0376 mL
50 mM	0.0483 mL	0.2415 mL	0.4830 mL	2.4151 mL
100 mM	0.0242 mL	0.1208 mL	0.2415 mL	1.2075 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc