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PQCA

Catalog No. T12531 CAS 1144504-35-7

PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.

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PQCA, CAS 1144504-35-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 132.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 563.00
25 mg	In stock	$ 891.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,670.00
500 mg	In stock	$ 3,350.00
1 mL * 10 mM (in DMSO)	In stock	$ 363.00

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Purity: 98.95%

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Description	PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.
Targets&IC50	M1 receptor (rhesus):49 nM (EC50), M1 receptor (human):135 nM (EC50), M1 receptor (human):135 nM (EC50), M1 receptor (rhesus):49 nM (EC50)
In vivo	In male rhesus monkeys, oral administration of PQCA (3-30 mg/kg) effectively mitigates the cognitive impairments induced by scopolamine in both the paired-associates learning (PAL) and the continuous performance task (CPT). Scopolamine-induced blockade of muscarinic signaling results in significant deficits in performance on both tasks. [1]

Molecular Weight	388.42
Formula	C22H20N4O3
CAS No.	1144504-35-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.0 mg/mL (23.2 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Lange HS, et al. The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. J Pharmacol Exp Ther. 2015;355(3):442-450. 2. Uslaner JM, et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl). 2013;225(1):21-30.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

PQCA 1144504-35-7 Neuroscience Others AChR inhibitor inhibit

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