Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,230.00 | |
50 mg | 10-14 weeks | $ 1,610.00 |
Description | PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay). |
Targets&IC50 | BACE1:7.3 nM , BACE2:194 nM |
In vitro | PF-06751979 shows improved selectivity over BACE2 (IC50=194 nM) in binding (27-fold) relative to the literature examples and across multiple chemical series in BACE1 program. |
In vivo | PF-06751979 displays excellent brain penetration, potent in vivo efficacy, and broad selectivity over related aspartyl proteases including BACE2. Acute administration of PF-06751979 yields a robust dose-responsive and time-dependent reduction of cerebral spinal fluid (CSF) Aβx-40 with peak inhibition at 3 h of >77%.[1]. |
Molecular Weight | 455.5 |
Formula | C18H19F2N5O3S2 |
CAS No. | 1818339-66-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL (109.77 mM), Sonication is recommended.
DMSO: 150 mg/mL (329.31 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-06751979 1818339-66-0 Neuroscience BACE PF06751979 PF 06751979 inhibitor inhibit