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Ombitasvir

Catalog No. T7158   CAS 1258226-87-7
Synonyms: ABT-267

Ombitasvir (ABT-267) is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a

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Ombitasvir Chemical Structure
Ombitasvir, CAS 1258226-87-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 77.00
10 mg In stock $ 126.00
25 mg In stock $ 240.00
50 mg In stock $ 433.00
100 mg In stock $ 638.00
500 mg In stock $ 1,370.00
1 mL * 10 mM (in DMSO) In stock $ 123.00
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Purity: 99.56%
Purity: 98.17%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ombitasvir (ABT-267) is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a
Targets&IC50 HCV genotype 6a:366 pM(EC50), HCV genotypes 1 to 5:0.82 pM-19.3 pM(EC50)
In vivo Ombitasvir was evaluated in vivo in a 3-day monotherapy study in 12 HCV genotype 1-infected patients at 5, 25, 50, or 200 mg dosed once daily. All patients were HCV genotype 1a infected and were without preexisting resistant variants at baseline as determined by clonal sequencing. Decreases in HCV RNA up to 3.1 log10 IU/ml were observed. Resistance-associated variants at position 28, 30, or 93 in NS5A were detected in patient samples 48 hours after the first dose. Clonal sequencing analysis indicated that wild-type virus was largely suppressed by ombitasvir during 3-day monotherapy, and at doses higher than 5 mg, resistant variant M28V was also suppressed. Ombitasvir was well tolerated at all doses, and there were no serious or severe adverse events. These data support clinical development of ombitasvir in combination with inhibitors targeting HCV NS3/4A protease (ABT-450 with ritonavir) and HCV NS5B polymerase (ABT-333, dasabuvir) for the treatment of chronic HCV genotype 1 infection[1].
Animal Research The patients in the ombitasvir dose groups were enrolled sequentially, and within each group, patients were randomized (2:1) to either ombitasvir or placebo and treated under nonfasting conditions for 3 days while confined to the study site. The 200-mg dose group received a different formulation with higher bioavailability. Patients who received at least one dose of ombitasvir or placebo were provided the option to receive treatment with pegIFN/RBV for approximately 48 weeks once treatment with ombitasvir was completed. HCV RNA was measured using the Roche COBAS TaqMan HCV Test v2.0 real-time reverse transcriptase PCR assay (with a lower limit of quantification of 25 IU/ml and a lower limit of detection of 10 IU/ml). The virologic response was assessed as HCV RNA decrease from baseline in log10 IU/ml[1].
Synonyms ABT-267
Molecular Weight 894.11
Formula C50H67N7O8
CAS No. 1258226-87-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (36.91 mM)

TargetMolReferences and Literature

1. Krishnan P, Beyer J, Mistry N,et al.in vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis c virus ns5a[J].Antimicrob Agents Chemother. 2015 Feb;59(2):979-87. 2. Keating, Gillian M . Ombitasvir/Paritaprevir/Ritonavir: A Review in Chronic HCV Genotype 4 Infection[J]. Drugs, 2016, 76(12):1203-1211.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max FDA-Approved Drug Library Clinical Compound Library Anti-COVID-19 Compound Library Anti-Aging Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Anti-Infection Compound Library Inhibitor Library Anti-Viral Compound Library

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Keywords

Ombitasvir 1258226-87-7 Microbiology/Virology Proteases/Proteasome HCV Protease Hepatitis C virus Inhibitor ABT267 inhibit HCV ABT 267 ABT-267 inhibitor

 

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