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Nucleocidin

Catalog No. T16361 CAS 24751-69-7

Synonyms: NSC 521007, 4'-Fluoro-5'-O-sulfamoyladenosine

Nucleocidin is an antitrypanosomal antibiotic. Nucleocidin inhibiting the transfer of labeled amino acid from S-RNA to protein.

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Nucleocidin, CAS 24751-69-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Nucleocidin is an antitrypanosomal antibiotic. Nucleocidin inhibiting the transfer of labeled amino acid from S-RNA to protein.

In vitro

Nucleocidin shows inhibition occurs at low concentrations, however, it is not possible to obtain complete inhibition at 10-3 M. Essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that Nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA. An appreciable lag occurs before any inhibition by Nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of Nucleocidin. Similar results are obtained when Nucleocidin is added to the cell-free system from reticulocytes .

Synonyms	NSC 521007, 4'-Fluoro-5'-O-sulfamoyladenosine
Molecular Weight	364.31
Formula	C10H13FN6O6S
CAS No.	24751-69-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nucleocidin 24751-69-7 代谢 NADPH NSC 521007 4'-Fluoro-5'-O-sulfamoyladenosine Inhibitor inhibitor inhibit

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