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Nucleocidin
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Catalog No. T16361Cas No. 24751-69-7
Alias NSC 521007, 4'-Fluoro-5'-O-sulfamoyladenosine
Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.
Nucleocidin
😃Good
Catalog No. T16361Alias NSC 521007, 4'-Fluoro-5'-O-sulfamoyladenosineCas No. 24751-69-7
Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein. |
| In vitro | Nucleocidin shows inhibition occurs at low concentrations, however, it is not possible to obtain complete inhibition at 10-3 M. Essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that Nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA. An appreciable lag occurs before any inhibition by Nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of Nucleocidin. Similar results are obtained when Nucleocidin is added to the cell-free system from reticulocytes . |
| Alias | NSC 521007, 4'-Fluoro-5'-O-sulfamoyladenosine |
| Molecular Weight | 364.31 |
| Formula | C10H13FN6O6S |
| Cas No. | 24751-69-7 |
| Relative Density. | 2.23g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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