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Niridazole

Catalog No. T28174 CAS 61-57-4

Synonyms: BA32644, BA-32644, Ambilhar, BA 32644

Niridazole (Ambilhar) is an antiparasitic compound belonging to nitroimidazoles. Niridazole is primarily used to treat schistosomiasis, which kills the parasite by interfering with its metabolism. Niridazole rapidly concentrates in the parasite, inhibits egg and sperm production, and inhibits phosphofructokinase activity.

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Niridazole, CAS 61-57-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 397.00
5 mg	In stock	$ 970.00
10 mg	In stock	$ 1,290.00
25 mg	In stock	$ 1,950.00
50 mg	In stock	$ 2,620.00
100 mg	In stock	$ 3,530.00

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Purity: 98.90%

Purity: 97.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Niridazole (Ambilhar) is an antiparasitic compound belonging to nitroimidazoles. Niridazole is primarily used to treat schistosomiasis, which kills the parasite by interfering with its metabolism. Niridazole rapidly concentrates in the parasite, inhibits egg and sperm production, and inhibits phosphofructokinase activity.
In vitro	The minimum inhibitory concentrations for niridazole ranged from 0.0037 to 1.0 microgram/ml [1]
In vivo	Niridazole, a human anthelminthic drug, is shown to be a potent long-acting suppressor of delayed hypersensitivity. Much lower doses than used in the therapy of helminth infections suppressed granuloma formation around Schistosoma mansoni eggs for periods up to 32 days and inhibited delayed footpad swelling in mice previously sensitized with eggs. Marked prolongation of skin allograft survival in mice across the H-2 area was produced.[2]

Synonyms	BA32644, BA-32644, Ambilhar, BA 32644
Molecular Weight	214.2
Formula	C6H6N4O3S
CAS No.	61-57-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1mg/ml, Sonication is recommended.

References and Literature

1. Hof H, et al. Comparative in vitro activities of niridazole and metronidazole against anaerobic and microaerophilic bacteria. Antimicrob Agents Chemother. 1982;22(2):332-333. 2. Mahmoud AA, Mandel A, Warren K, Webster LT Jr. Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity. J Immunol. 1975;114(1 Pt 2):279-283. 3. Wade WG, Addy M. Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. J Appl Bacteriol. 1987 Nov;63(5):455-7. PubMed PMID: 3440767. 4. Ma Z, Si BX, Liu YL, Huang LS. [Synthesis of acylates of niridazole and its analogs as schistosomicides]. Yao Xue Xue Bao. 1989;24(6):476-80. Chinese. PubMed PMID: 2609988.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Niridazole 61-57-4 BA32644 BA-32644 Ambilhar BA 32644 inhibitor inhibit

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