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Namodenoson

Catalog No. T6884 CAS 163042-96-4

Synonyms: 2-Cl-IB-MECA, CF-102

Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

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Namodenoson, CAS 163042-96-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 597.00
1 mL * 10 mM (in DMSO)	In stock	$ 87.00

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Purity: 99.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.
Targets&IC50	A3 receptor:0.33 nM (Ki)
In vivo	The first infusion of 2-Cl-IB-MECA resulted in a rapid fall of the blood pressure to a value which was about 50% of the pre-administration level.?The hypotension was short-lasting.?After approximately 15 min the blood pressure started to recover and rapidly returned to stable values, which were significantly lower than the blood pressure values in the control group.?Administration of the second dose of 2-Cl-IB-MECA, at 150 min after the first infusion, did not produce any hypotension at all.?The slight increase in the mean arterial pressure during the second infusion was not specific for 2-Cl-IB-MECA[1]
Animal Research	Rats were randomly assigned to two treatment groups of 6 animals, which received either two subsequent intravenous infusions of 200 μg/kg 2-chloro-N^6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (2-Cl-IB-MECA) during 15 min or two subsequent infusions of the vehicle during 15 min. 2-Cl-IB-MECA was dissolved in dimethylsulfoxide (DMSO) and diluted with a sodium chloride solution to a final 30% (v/v) DMSO solution (a total volume of 765 μl).?Fresh solutions were prepared prior to each experiment.The effect measurements were started at least 45 min prior to the first drug infusion and lasted until 4.5 h after this infusion.?Heart rate and blood pressure were recorded continuously and serial arterial blood samples were drawn for determination of plasma histamine concentrations.?2 h after the first administration the second dose of 2-Cl-IB-MECA (or vehicle) was administered[1].

Synonyms	2-Cl-IB-MECA, CF-102
Molecular Weight	544.73
Formula	C18H18ClIN6O4
CAS No.	163042-96-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31 mg/mL (56.91 mM)

References and Literature

1. Schaick E A V , Jacobson K A , Kim H O , et al. Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats[J]. European Journal of Pharmacology, 1996, 308(3):0-314. 2. Yuan K , Bai G Y , Park W H , et al. Stimulation of ANP secretion by 2-Cl-IB-MECA through A3 receptor and CaMKII[J]. Peptides, 2008, 29(12):0-2224.

Citations

1. Cai H, Guo S, Xu Y, et al.Cryo-EM structures of adenosine receptor A3AR bound to selective agonists.Nature Communications.2024, 15(1): 3252.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library GPCR Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Nucleotide Compound Library Anti-Obesity Compound Library Neuronal Signaling Compound Library Covalent Inhibitor Library

Related Products

Related compounds with same targets

Adenosine 5'-monophosphate monohydrate N6-Ethyladenosine PSB-603 5-Iodotubercidin Taminadenant Preladenant N6-Cyclopentyladenosine GS-9667

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Namodenoson 163042-96-4 GPCR/G Protein Neuroscience Adenosine Receptor 2-Cl-IB-MECA CF 102 CF-102 inhibit Inhibitor P1 receptor CF102 inhibitor

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