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N-(m-PEG4)-N'-(azide-PEG4)-Cy3

Catalog No. T18424 CAS 2107273-38-9

N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a polyethylene glycol (PEG)-derived linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

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N-(m-PEG4)-N'-(azide-PEG4)-Cy3, CAS 2107273-38-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a polyethylene glycol (PEG)-derived linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	800.42
Formula	C42H62ClN5O8
CAS No.	2107273-38-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-(m-PEG4)-N'-(azide-PEG4)-Cy3 2107273-38-9 Others N (m PEG4) N' (azide PEG4) Cy3 N(mPEG4)N'(azidePEG4)Cy3 N-(m-PEG-4)-N'-(azide-PEG4)-Cy3 inhibitor inhibit

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