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Musk ketone

Catalog No. T5654 CAS 81-14-1

Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.

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Musk ketone, CAS 81-14-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 43.00
100 mg	In stock	$ 62.00
500 mg	In stock	$ 145.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 98%

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Description	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.
In vitro	Similar to native musk, synthetic musk ketone induced the growth repression and the apoptosis of cancer cells. Additionally, numerous genes were differentially expressed in lung cancer cells after native musk treatment. These differentially expressed genes were involved in many signalling pathways. Among these pathways, apoptosis-related pathways included interleukin family, tumor necrosis factor family, and MAPK signalling pathway. Native musk and synthetic musk ketone can up-regulate IL-24 (interleukin family) and DDIT3 (MAPK signalling pathway) in lung cancer cells[1].
In vivo	Musk ketone can reduce secondary damage after spinal cord injury and promote nerve recovery in rats[2].
Cell Research	Twenty two cancer cell lines were treated with musk. Cell proliferation and apoptosis analyses were carried out. Native musk and synthetic?musk ketone?were analyzed by gas chromatograph-mass spectrometer (GC-MS) assay. Differentially expressed genes were determined by microarray and quantitative real-time polymerase chain reaction.
Animal Research	The rats weighed from 200 to 250 g and ?were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).?The Swash plate test and BBB behavioral score were used to determine neurological function recovery after spinal cord injury.?Hematoxylin-eosin (HE) staining was used to detect general structural changes in spinal cord tissue.?The enzyme-linked immunosorbent assay was used for the determination of interleukin 10 (IL-10) in spinal cord tissue.??Compared with the NS control group, critical angle, BBB score and IL-10 levels in rat spinal cord tissue significantly increased in the MP group and MO groups 7 and 14 days after the operation.?HE staining showed that in the NS group, there was hemorrhage, edema, necrosis, axonal demyelination, inflammatory cell infiltration and glial cell response in spinal cord tissue.?After 7 days, spinal cord edema and inflammation were reduced and neuronal degeneration and necrosis were not evident in the MP and MO groups[2].

Molecular Weight	294.3
Formula	C14H18N2O5
CAS No.	81-14-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (84.95 mM)

References and Literature

1. Xu L , Cao Y . Native musk and synthetic musk ketone strongly induced the growth repression and the apoptosis of cancer cells[J]. BMC Complementary and Alternative Medicine, 2016, 16(1). 2. Guo L , Quan Z X , Zhao Z H , et al. Effects of musk ketone on nerve recovery after spinal cord injury[J]. Genetics and molecular research: GMR, 2015, 14(2):2958-2963.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Human Endogenous Metabolite Compound Library Plus NO PAINS Compound Library RO5 Drug-like Natural Product Library Natural Product Library for HTS Bioactive Compound Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Human Metabolite Library Anti-Cancer Compound Library

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Keywords

Musk ketone 81-14-1 Others Apoptosis inhibit Hep G2 PI3K/Akt neuroprotective Protein kinase B Inhibitor PKB cerebral ischemia PI3K Akt Phosphoinositide 3-kinase inhibitor

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