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Methyltetrazine-PEG4-SS-PEG4-methyltetrazine

Catalog No. T18352 CAS T18352

Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit polyethylene glycol (PEG) linker, employed for the synthesis of antibody-drug conjugates (ADCs)[1].

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Methyltetrazine-PEG4-SS-PEG4-methyltetrazine, CAS T18352

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit polyethylene glycol (PEG) linker, employed for the synthesis of antibody-drug conjugates (ADCs)[1].
In vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight	1071.27
Formula	C48H70N12O12S2
CAS No.	T18352

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methyltetrazine-PEG4-SS-PEG4-methyltetrazine T18352 Others Methyltetrazine-PEG-4-SS-PEG4-methyltetrazine Methyltetrazine PEG4 SS PEG4 methyltetrazine MethyltetrazinePEG4SSPEG4methyltetrazine inhibitor inhibit

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