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Mesoridazine free base

Catalog No. T3086L CAS 5588-33-0

Synonyms: NSC-186066, NSC 186066, NSC186066, TPS23, Mesoridazine, NC-123

Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mesoridazine free base Chemical Structure

Mesoridazine free base, CAS 5588-33-0

Pack Size	Availability	Price/USD
10 mg	35 days	$ 93.00
25 mg	35 days	$ 198.00
50 mg	35 days	$ 378.00
100 mg	35 days	$ 665.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.

Synonyms	NSC-186066, NSC 186066, NSC186066, TPS23, Mesoridazine, NC-123
Molecular Weight	386.57
Formula	C21H26N2OS2
CAS No.	5588-33-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Im SH, Park MJ, Seo H, Choi SH, Kim SK, Ahn SH. Determination of mesoridazine by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:117-23. doi: 10.1016/j.jchromb.2014.03.020. Epub 2014 Mar 24. PubMed PMID: 24732149. 2. Liu KS, Chen YW, Aljuffali IA, Chang CW, Wang JJ, Fang JY. Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: The skin absorption assessment. Eur J Pharm Biopharm. 2016 Aug;105:59-68. doi: 10.1016/j.ejpb.2016.05.025. Epub 2016 May 31. PubMed PMID: 27260201. 3. Salih IS, Thanacoody RH, McKay GA, Thomas SH. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses. Clin Pharmacol Ther. 2007 Nov;82(5):548-54. Epub 2007 Apr 4. PubMed PMID: 17410120. 4. Charalampous KD, Johnson PC, Estevez V. Absorption and excretion of thioridazine and mesoridazine in man. Dis Nerv Syst. 1974 Nov;35(11):494-6. PubMed PMID: 17896456.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mesoridazine free base 5588-33-0 NC123 NSC-186066 NC 123 NSC 186066 TPS-23 NSC186066 TPS23 Mesoridazine TPS 23 NC-123 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.