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Mal-PEG6-PFP ester

Catalog No. T16002 CAS 1599486-33-5

Mal-PEG6-PFP ester is a PEG-based PROTAC Linker that can be used in the synthesis of PROTACs[1].

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Mal-PEG6-PFP ester, CAS 1599486-33-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	599.5
Formula	C25H30F5NO10
CAS No.	1599486-33-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mal-PEG6-PFP ester 1599486-33-5 Others Mal-PEG-6-PFP ester MalPEG6PFP ester Mal PEG6 PFP ester inhibitor inhibit

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