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Mal-PEG4-Lys(t-Boc)-NH-m-PEG24

Catalog No. T18286 CAS T18286

Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of PROTACs[1].

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Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 Chemical Structure

Mal-PEG4-Lys(t-Boc)-NH-m-PEG24, CAS T18286

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	1715.01
Formula	C78H147N5O35
CAS No.	T18286

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 T18286 Others MalPEG4Lys(tBoc)NHmPEG24 Mal-PEG-4-Lys(t-Boc)-NH-m-PEG24 Mal PEG4 Lys(t Boc) NH m PEG24 inhibitor inhibit

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