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MGS-0039

Catalog No. T28034 CAS 569686-87-9

Synonyms: BCI 632, BCI-632, MGS0039, BCI632

MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors.

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MGS-0039, CAS 569686-87-9

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,970.00
50 mg	8-10 weeks	$ 2,580.00
100 mg	8-10 weeks	$ 3,400.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	BCI 632, BCI-632, MGS0039, BCI632
Molecular Weight	378.18
Formula	C15H14Cl2FNO5
CAS No.	569686-87-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pałucha-Poniewiera A, Wierońska JM, Brański P, Stachowicz K, Chaki S, Pilc A. On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039. Psychopharmacology (Berl). 2010 Dec;212(4):523-35. doi: 10.1007/s00213-010-1978-5. PubMed PMID: 20703449; PubMed Central PMCID: PMC2981731. 2. Koike H, Iijima M, Chaki S. Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists. Neuropharmacology. 2011 Dec;61(8):1419-23. doi: 10.1016/j.neuropharm.2011.08.034. PubMed PMID: 21903115. 3. Stachowicz K, Wierońska J, Domin H, Chaki S, Pilc A. Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin- and GABA-dependent. Pharmacol Rep. 2011;63(4):880-7. PubMed PMID: 22001975. 4. Shimazaki T, Kaku A, Chaki S. Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur J Pharmacol. 2007 Dec 1;575(1-3):94-7. PubMed PMID: 17727837.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MGS-0039 569686-87-9 BCI 632 BCI-632 MGS 0039 MGS0039 BCI632 inhibitor inhibit

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