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Lidamidine

Catalog No. T25719 CAS 66871-56-5

Synonyms: Lidamidina, Lidamidinum

Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.

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Lidamidine, CAS 66871-56-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 437.00
10 mg	In stock	$ 646.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,860.00

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Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.

In vivo

Fasted male rats were anesthetised and equipped with an intraluminal cannula positioned at the proximal end of a 10 cm fluid-filled segment of the ascending colon (basal pressure, 10 cm H2O). Intraluminal pressure was monitored by a transducer attached to a closed fluid-filled system. All drugs were administered intravenously by slow infusion. A regular pattern of distinct contractile complexes was observed over a 70 min period. These contractions increased intraluminal pressure to 39 +/- 1.2 cm H2O (mean +/- S.E.), occurred at a frequency of 0.3 per min and lasted from 1 to 2.5 min. Inhibition of these contractile patterns was observed with either atropine (0.1 mg/kg) or lidamidine (3.0 mg/kg). A 20 min pretreatment with idazoxan (3.0 mg/kg) antagonized lidamidine's but not atropine's effect. Trimazosin (1 mg/kg) or propranolol (0.3 mg/kg) pretreatment did not antagonize the lidamidine-generated inhibition[1].

Synonyms	Lidamidina, Lidamidinum
Molecular Weight	220.27
Formula	C11H16N4O
CAS No.	66871-56-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (22.7 mM)

References and Literature

1. Eaker EY, Bixler GB, Mathias JR. WHR 1049, a potent metabolite of lidamidine, has antidiarrheal and antimotility effects on the small intestine in rats. J Pharmacol Exp Ther. 1988 Aug;246(2):786-9. PubMed PMID: 3404458. 2. Wienbeck M, Bohn M. Different actions of 2 antidiarrheal agents, lidamidine and loperamide, on motility of the isolated cat colon muscle. Z Gastroenterol. 1985 Apr;23(4):175-82. PubMed PMID: 4060808. 3. Awad RA, Llorens F, Camelo AL, Sánchez M. A randomised double-blind placebo-controlled trial of lidamidine HCL in irritable bowel syndrome. Acta Gastroenterol Latinoam. 2000;30(3):169-75. PubMed PMID: 10975022. 4. Bleakman D, Naftalin RJ. Prevention of guanine nucleotide-induced reductions in muscarinic agonist binding to rabbit ileal submucosal membranes by lidamidine and tetracaine. Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):366-72. PubMed PMID: 2900471.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Human Metabolite Library ReFRAME Related Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lidamidine 66871-56-5 Others Lidamidina Lidamidinum inhibitor inhibit

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