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Lauric Acid

Catalog No. T6873 CAS 143-07-7

Synonyms: Dodecylic acid, dodecanoic acid, Vulvic acid, N-Dodecanoic acid

Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.

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Lauric Acid, CAS 143-07-7

Pack Size	Availability	Price/USD
500 mg	In stock	$ 46.00
1 g	In stock	$ 55.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.
Targets&IC50	S. epidermidis:4 μg/mL(EC50), P. acnes:2μg/mL(EC50), S. aureus:6μg/mL(EC50)
In vitro	Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS[1].
Kinase Assay	JAK2 and other human kinase activity assays: JAK2 kinase activity was assessed with the HTScan JAK2 Kinase Assay Kit per manufacturer's protocol. The possible effects of FLLL32 on the other 10 purified human protein kinases were determined by using a Kinase Profiler Assay.
Cell Research	Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 105 and 1.5 × 105 cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO2 and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate. (Only for Reference)
Source	Natural Products > Arecaceae > Trachycarpus

Synonyms	Dodecylic acid, dodecanoic acid, Vulvic acid, N-Dodecanoic acid
Molecular Weight	200.32
Formula	C12H24O2
CAS No.	143-07-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 38 mg/mL (189.7 mM)

DMSO: 38 mg/mL (189.7 mM)

H2O: 16 mg/mL (79.9 mM)

References and Literature

1. Fauser JK, et al. Chemotherapy. 2013, 59(3):214-24.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Traditional Chinese Medicine Monomer Library Tobacco Monomer Library Drug Repurposing Compound Library Miao medicine Compound Library Microbial Natural Product Library Human Endogenous Metabolite Library Natural Product Library for HTS Anti-Bacterial Compound Library PBCRBS Traditional Chinese Medicine Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Lauric Acid 143-07-7 Metabolism Microbiology/Virology Others Endogenous Metabolite Antibacterial Inhibitor Dodecylic acid Bacterial dodecanoic acid inhibit Vulvic acid N-Dodecanoic acid inhibitor

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