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L524-0366

Catalog No. T8570 CAS 951612-19-4

Synonyms: [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone

L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

L524-0366, CAS 951612-19-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 134.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 453.00
25 mg	In stock	$ 769.00
50 mg	In stock	$ 995.00
100 mg	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 96.31%

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Description	L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.
In vitro	L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
Cell Research	Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.

Synonyms	[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
Molecular Weight	308.79
Formula	C13H13ClN4OS
CAS No.	951612-19-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.09 mg/mL (10 mM)

References and Literature

1. Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.

Citations

1. Li Z, Wang H, Zhu J, et al. Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis. Cell Death Discovery. 2022, 8(1): 1-11

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

L524-0366 951612-19-4 Others L524 0366 [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone L5240366 L-524-0366 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.