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L-6424

Catalog No. T20143 CAS 147030-50-0

Synonyms: L 6424, Amiodarone related compound G

L-6424 is an intermediate of Amiodarone and a non-selective ion channel blocker. It has an antiarrhythmic.

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L-6424, CAS 147030-50-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

L-6424 is an intermediate of Amiodarone and a non-selective ion channel blocker. It has an antiarrhythmic.

Synonyms	L 6424, Amiodarone related compound G
Molecular Weight	420.24
Formula	C19H17IO3
CAS No.	147030-50-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Garcia-Doval C, Castón JR, Luque D, Granell M, Otero JM, Llamas-Saiz AL, Renouard M, Boulanger P, van Raaij MJ. Structure of the Receptor-Binding Carboxy-Terminal Domain of the Bacteriophage T5 L-Shaped Tail Fibre with and without Its Intra-Molecular Chaperone. Viruses. 2015 Dec 8;7(12):6424-40. doi: 10.3390/v7122946. PubMed PMID: 26670244; PubMed Central PMCID: PMC4690869. 2. Pana ZD, Samarah F, Papi R, Antachopoulos C, Papageorgiou T, Farmaki E, Hatzipantelis E, Tragiannidis A, Vavatsi-Christaki N, Kyriakidis D, Athanassiadou-Piperopoulou F, Roilides E. Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. Pediatr Blood Cancer. 2014 Jun;61(6):1017-22. doi: 10.1002/pbc.24951. Epub 2014 Jan 22. PubMed PMID: 24453114. 3. Kilpatrick DC, St Swierzko A, Matsushita M, Domzalska-Popadiuk I, Borkowska-Klos M, Szczapa J, Cedzynski M. The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates. Hum Immunol. 2013 Jul;74(7):867-71. doi: 10.1016/j.humimm.2013.04.011. Epub 2013 Apr 22. PubMed PMID: 23619474. 4. Harada H, Yamashita Y, Misumi K, Tsubokawa N, Nakao J, Matsutani J, Yamasaki M, Ohkawachi T, Taniyama K. Multidisciplinary team-based approach for comprehensive preoperative pulmonary rehabilitation including intensive nutritional support for lung cancer patients. PLoS One. 2013;8(3):e59566. doi: 10.1371/journal.pone.0059566. Epub 2013 Mar 15. PubMed PMID: 23555043; PubMed Central PMCID: PMC3598743.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-6424 147030-50-0 L 6424 L6424 Amiodarone related compound G inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.