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KDM4-IN-2

Catalog No. T11749 CAS 2369607-62-3

KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.

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KDM4-IN-2, CAS 2369607-62-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
Targets&IC50	KDM4B:43±21 nM , KDM5C:123 nM , KDM5B:38 nM , KDM5B:7 nM (ki), KDM4A:(ki)4 nM , KDM4A:100±41 nM , KDM2A:4.50 μM , KDM6B:90.22 μM , KDM3A:5.78 μM

Molecular Weight	426.51
Formula	C25H26N6O
CAS No.	2369607-62-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KDM4-IN-2 2369607-62-3 代谢 Glucokinase KDM4 IN 2 KDM-4-IN-2 KDM4IN2 Inhibitor inhibitor inhibit

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