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KB-5246

Catalog No. T11744 CAS 119474-55-4

KB-5246, displays <a href="/target/Antibacterial" style="display: inline; color: #c13a36">Antibacterial</a> activities.is a tetracyclic quinolone.

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KB-5246, CAS 119474-55-4

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1,070.00
50 mg	8-10 weeks	$ 2,180.00
100 mg	8-10 weeks	$ 2,800.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
In vitro	KB5246 inhibits 90% of isolates of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca at a concentration of 0.10 μg/mL or less. When a concentration of KB-5246 at the MIC or higher is added, no regrowth after 24 h of incubation is observed.KB-5246 is a tetracyclic quinolone and displays antibacterial activities. The MICs for 90% of isolates tested (MIC90s) of KB-5246 against gram-positive microorganisms such as Staphylococcus aureus, including methicillin-resistant S. aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes, are 0.39 μg/mL.
In vivo	The 50% effective dose values of KB-5246 against S. pneumoniae 2132 infections are 50.5 mg/kg of body weight. The activities of KB-5246 against S. aureus Smith, P. aeruginosa GN11189, and Serratia marcescens GN7577 infections are comparable to those of ofloxacin and greater than those of norfloxacin.

Molecular Weight	425.86
Formula	C18H17ClFN3O4S
CAS No.	119474-55-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kotera Y, et al. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KB-5246 119474-55-4 GPCR/G Protein MAPK Ras KB 5246 KB5246 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.