Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 258.00 | |
5 mg | In stock | $ 642.00 | |
10 mg | In stock | $ 913.00 | |
25 mg | In stock | $ 1,370.00 | |
50 mg | In stock | $ 1,850.00 | |
100 mg | In stock | $ 2,500.00 |
Description | Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection. |
In vivo | Isatoribine is a selective agonist of TLR7. In a proof-of-concept study, we found that once-daily 7-day treatment with intravenous Isatoribine 800 mg caused a significant (P = .001) reduction of plasma HCV RNA (mean, -0.76; range, -2.85 to +0.21 log(10) units) in otherwise untreated patients (n = 12) who were chronically infected with HCV. Viral load reduction occurred in patients infected with genotype 1 as well as non-genotype 1 HCV. The reduction of viral load was correlated with the induction of markers of a heightened immune antiviral state, including 2'-, 5'- oligoadenylate synthetase levels in whole blood. This treatment was well tolerated, with a low frequency of mild to moderate adverse events. In conclusion, systemic administration of the selective TLR7 agonist Isatoribine resulted in dose-dependent changes in immunologic biomarkers and a statistically significant antiviral effect with relatively few and mild side effects.[1] |
Synonyms | Isatoribine free base, ANA 245, Immusine, ANA-245, Isatoribine, Isatoribine monohydrate, ANA245 |
Molecular Weight | 316.29 |
Formula | C10H12N4O6S |
CAS No. | 122970-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Isatoribine 122970-40-5 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome HCV Protease TLR Isatoribine free base ANA 245 Immusine ANA-245 Isatoribine Monohydrate Isatoribine monohydrate ANA245 inhibitor inhibit