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Imipenem monohydrate
🥰Excellent
Catalog No. T1505Cas No. 74431-23-5
Alias N-Formimidoyl thienamycin monohydrate
Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.
Imipenem monohydrate
🥰Excellent
Purity: 99.94%
Catalog No. T1505Alias N-Formimidoyl thienamycin monohydrateCas No. 74431-23-5
Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $53 | In Stock | |
| 200 mg | $79 | In Stock |
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Purity:99.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria. |
| In vivo | METHODS: To study the effect on tuberculosis, Imipenem monohydrate (100 mg/kg) was administered subcutaneously to a mouse model of tuberculosis twice daily for 28 days. RESULTS: Imipenem significantly reduced the number of Mycobacterium tuberculosis in the lungs and spleens, and increased the survival rate of the mice. [1] METHODS: To assess the effect on the kinetics of the inflammatory response in a mouse model of sepsis, Imipenem monohydrate (25-125 mg/kg) was administered subcutaneously to CLP-induced septic mice once daily for three days. RESULTS: Subcutaneous injection of Imipenem had a dose-dependent effect on the inflammatory response in septic mice. In septic mice, the 25 mg/kg dose of Imipenem resulted in better pathology, lower inflammatory mediators and improved survival. [2] |
| Synonyms | N-Formimidoyl thienamycin monohydrate |
| Molecular Weight | 317.36 |
| Formula | C12H19N3O5S |
| Cas No. | 74431-23-5 |
| Smiles | O.[H][C@]12CC(SCCNC=N)=C(N1C(=O)[C@@H]2[C@@H](C)O)C(O)=O |
| Relative Density. | 1.02 g/mL at 25 °C |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 6.67 mg/mL (21.02 mM), Sonication is recommended. DMSO: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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